Title:
【発明の名称】副腎皮質刺激ホルモン放出因子レセプター-1欠損マウス
Document Type and Number:
Japanese Patent JP2002509736
Kind Code:
A
Abstract:
Signaling pathways dependent on members of the corticotropin releasing factor (CRF) gene family exert pleiotropic effects within both the brain and peripheral tissues. Two biochemically and pharmacologically distinct corticotropin releasing factor receptor subtypes (corticotropin releasing factor receptor-1 and corticotropin releasing factor receptor-2) have been described. To study the developmental and physiological role of the specific receptor subtypes, a strain of mice null for the corticotropin releasing factor receptor-1 gene has been generated. This genetically engineered strain of mice suggest that corticotropin releasing factor receptor-1 is obligatory both in development and function of the hypothalamic-pituitary-adrenal axis and in mediating behavioral changes associated with anxiety and locomotor activity rhythms.
Inventors:
Lee, Quo-Fen
Weil, Vail
Weil, Vail
Application Number:
JP2000541515A
Publication Date:
April 02, 2002
Filing Date:
March 30, 1999
Export Citation:
Assignee:
Research Development Foundation
International Classes:
A61K31/56; A61K31/573; A61P11/00; C07K2/00; C07K14/72; C12N15/00; C12N15/09; C12N15/85; G01N33/15; A01K67/027; G01N33/50; G01N33/53; (IPC1-7): A01K67/027; A61K31/56; A61P11/00; C12N15/00; C12N15/09; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Morio Sada