Title:
【発明の名称】肝臓で代謝される薬物前駆物の決定とその治療的利用
Document Type and Number:
Japanese Patent JPH06507902
Kind Code:
A
Abstract:
PCT No. PCT/US92/04142 Sec. 371 Date Apr. 19, 1994 Sec. 102(e) Date Apr. 19, 1994 PCT Filed May 15, 1992A method of ascertaining if a prodrug is useful for treating a disease is disclosed. The prodrug is acceptable if it is metabolized in liver cells by aldehyde oxidase to produce an active drug or metabolite. Prodrugs are shown equally effective in treating diseases as the active drug itself with many benefits and without as many associated side effects. Methods for treating cancers with 5-iodo-2-pyrimidinone-deoxyribose and 5-fluoro-2-pyrimidinone are also described.
Inventors:
Chen, Yun-chi
Chang, Chen-Nen
Chang, Chen-Nen
Application Number:
JP50024093A
Publication Date:
September 08, 1994
Filing Date:
May 15, 1992
Export Citation:
Assignee:
YALE UNIVERSITY
International Classes:
A61K31/505; A61K31/513; A61K31/52; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7076; A61K45/00; A61P35/00; A61P43/00; C07D239/22; C07D239/34; C07D239/42; C07D405/04; C07D473/32; C07H19/04; C07H19/06; G01N33/50; (IPC1-7): A61K45/00; A61K31/505; A61K31/52; A61K31/70; C07D239/22; C07D239/34; C07D239/42; C07D405/04; C07D473/32; C07H19/06
Attorney, Agent or Firm:
Naoki Fukumura