Title:
【発明の名称】GSK-3阻害剤としてのジアミノ-1,2,4-トリアゾール-カルボン酸誘導体
Document Type and Number:
Japanese Patent JP2003506362
Kind Code:
A
Abstract:
Pharmaceutical compositions comprising compounds of formula (I), or a pharmaceutically acceptable derivative thereof, and a pharmaceutically acceptable carrier wherein; the R<3>CZ-moiety may be attached to the nitrogen atom at position 1 or the nitrogen atom at position 2; R<1> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic; R<2> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic, or R<1> and R<2> together with the nitrogen atom to which they are attached may form a heterocyclic ring which ring may be unsubstituted or substituted; R<3> is alkyl, aryl, aralkyl, aryl(Q)alkyl, where Q is O or S, aralkenyl, alicyclic, heteroaryl, heteroaralkyl, arylcarbonylalkyl, alicyclylalkyl, diarylalkyl, or NR<6>R<7>; R<4> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic; R<5> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic, or R<4> and R<5> together with the nitrogen atom to which they are attached may form a heterocyclic ring which ring may be unsubstituted or substituted; R<6> is hydrogen, aryl or alicyclic; R<7> is hydrogen, aryl or alicyclic, and: Z is oxygen or sulphur; are indicated to be useful in the treatment of conditions associated with a need for inhibition of GSK-3.
Inventors:
David Glyn Smith
Robert William Ward
Robert William Ward
Application Number:
JP2001514309A
Publication Date:
February 18, 2003
Filing Date:
July 31, 2000
Export Citation:
Assignee:
SmithKline Beechham Public Limited Company
International Classes:
A61K31/4196; A61P3/10; A61P7/12; A61P25/20; A61P25/24; A61P25/28; A61P43/00; C07D249/14; C07D401/06; C07D401/12; C07D403/12; C07D405/06; C07D405/12; C07D409/12; (IPC1-7): A61K31/4196; A61P3/10; A61P25/20; A61P25/24; A61P25/28; A61P43/00; C07D249/14; C07D401/12; C07D403/12; C07D405/12; C07D409/12
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)