Title:
【発明の名称】ドーパミンD3レセプター拮抗薬用5-(2-オキシフェニル)-ピロール誘導体
Document Type and Number:
Japanese Patent JPH07509705
Kind Code:
A
Abstract:
PCT No. PCT/EP93/02030 Sec. 371 Date Feb. 3, 1995 Sec. 102(e) Date Feb. 3, 1995 PCT Filed Jul. 29, 1993 PCT Pub. No. WO94/03426 PCT Pub. Date Feb. 17, 1994.Compounds of formula (I), formula (I) (a) or (b) wherein R1 represents C1-4alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyalkyl, C1-4alkylthio, C1-4alkanoyl, C1-4alkoxycarbonyl, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or R1 and R2 together form a linking chain-(CH2)mOp (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C1-4alkyl groups; and Y represents a group selected from (a) or (b) wherein R6 and R7 independently represent hydrogen, C1-6alkyl, optionally substituted arylC1-6alkyl or optionally substituted heteroarylC1-6alkyl; R8 represents C1-6alkyl, C3-6alkenyl or C3-6cycloalkylC1-4alkyl; and R9 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; or NR8R9 forms a heterocyclic ring (with the proviso that NR8R9 is not piperazine); R10 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl, or optionally substituted heteroarylC1-4alkyl; and n is 1 to 3; and salts thereof, have affinity for dopamine D3 receptors and may be useful in the treatment of e.g., psychotic disorders.
Inventors:
Jeff, Jeff
Hadley, Michael Stuart
Nash, David John
Johnson, Christopher Nobert
Hadley, Michael Stuart
Nash, David John
Johnson, Christopher Nobert
Application Number:
JP50499094A
Publication Date:
October 26, 1995
Filing Date:
July 29, 1993
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/40; A61K31/4025; A61P25/18; C07D207/335; C07D209/52; C07D221/22; C07D221/24; C07D401/06; C07D403/04; C07D401/04; C07D405/04; C07D405/12; C07D409/12; C07D451/02; C07D451/14; C07D453/06; C07D471/08; C07D207/32; (IPC1-7): C07D207/335; A61K31/40; C07D401/04; C07D401/06; C07D403/04; C07D405/04; C07D451/02; C07D451/14; C07D471/08
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)