Title:
【発明の名称】ダイネマイシン類似化合物:合成、処方並びに使用方法
Document Type and Number:
Japanese Patent JPH06500115
Kind Code:
A
Abstract:
2088499 9202522 PCTABS00010 A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods of preparing a compound.
Inventors:
One Chan Ko
Smith Adrian El
Wende Vaughn Sebastian Vi
Nikolau Kyria Kossee
Shriner Elwin Pee
Stall wilhelm
Dai Way Min
Smith Adrian El
Wende Vaughn Sebastian Vi
Nikolau Kyria Kossee
Shriner Elwin Pee
Stall wilhelm
Dai Way Min
Application Number:
JP51584691A
Publication Date:
January 06, 1994
Filing Date:
July 31, 1991
Export Citation:
Assignee:
Scripps Clinic And Research Foundation
International Classes:
A61K31/435; A61K31/395; A61K31/47; A61K31/70; A61K31/7042; A61P35/00; C07D491/044; C07D491/08; C07D498/08; C07H15/26; C07H17/00; C07K16/30; A61K; C07D; C07H; (IPC1-7): C07D491/08; A61K31/435; A61K31/71; C07H17/00
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)