Title:
【発明の名称】エストラ-1,3,5(10)-トリエン-7α-チオエーテル
Document Type and Number:
Japanese Patent JP2001520235
Kind Code:
A
Abstract:
The invention provides estrogens and antiestrogens of formula (I) having structure (I) wherein R is (II), (III), (IV), or (V); R<1> and R<2> are each, independently, alkyl of 1-6 carbon atoms, or are alkyl groups which are taken together to form a 5-7 membered satured heterocycle; X is hydroxy, alkoxy of 1-6 carbon atoms, or -OC(O)R<3>; W is (VI), hydroxy, alkyl of 1-6 carbon atoms, halogen, -CF3, alkoxy of 1-6 carbon atoms, -CHO, cyano, alkylcarbonyl of 2-7 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, trifluoromethoxy, hydroxyalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, -CN, -SO3H, or -CO2H; R<3> is alkyl of 1-6 carbon atoms; Z is (VII), (VIII), (IX), or (X); Y is (XI), (XII), or (XIII); R<4> is hydrogen, alkyl of 1-6 carbon atoms, alkoyl of 2-7 carbon atoms, or benzoyl; Q is hydrogen, -OR<5>, or -NR<6>R<7>; R<5> is hydrogen or alkyl of 1-6 carbon atoms; R<6> and R<7> are each, independently, alkyl of 1-6 carbon atoms, or are alkyl groups which are taken together to form a 5-7 membered saturated heterocycle; n = 4-12; and p = 2-6; or a pharmaceutically acceptable salt thereof.
Inventors:
Christopher Paul Miller
Aibo Zirkovsky
Buck Ding Trang
Aibo Zirkovsky
Buck Ding Trang
Application Number:
JP2000516987A
Publication Date:
October 30, 2001
Filing Date:
October 21, 1998
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
A61K31/565; A61K31/566; A61K31/59; A61P9/00; A61P11/00; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/06; A61P31/20; A61P37/06; C07J31/00; C07J41/00; C07J43/00; (IPC1-7): C07J31/00; A61K31/565; A61K31/566; A61K31/59; A61P9/00; A61P11/00; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/06; A61P31/20; A61P37/06; C07J41/00; C07J43/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)