Title:
【発明の名称】細胞サイクルによって制御される細胞に特異的な活性化合物を用いる、免疫系に関連した疾病の遺伝子療法
Document Type and Number:
Japanese Patent JP2002502228
Kind Code:
A
Abstract:
A DNA sequence is described for the gene therapy of diseases associated with the immune system. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated in a cell-specific or virus-specific manner and this activation is regulated by the promoter module in a cell cycle-specific manner. The choice of activator sequence and active substance depends on the indication area. The DNA sequence is inserted into a viral or non-viral vector which is supplemented by a ligand having affinity for the target cell. Depending on the choice of activator sequence and active substance, the following can be treated by administering the DNA sequence: defective formation of blood cells autoimmune diseases and allergies and, in addition, rejection reactions against transplanted organs chronic arthritis viral and parasitic infections and, in addition, prophylaxis of viral, bacterial and parasitic infections, and leukaemias.
Inventors:
Zedrazeck, Hans-Halalt
Muller, Rolf
Muller, Rolf
Application Number:
JP50848096A
Publication Date:
January 22, 2002
Filing Date:
August 25, 1995
Export Citation:
Assignee:
Hoechst, Akchen Gezel Shaft
International Classes:
A61K31/711; A61K38/00; A61K38/21; A61K38/22; A61K38/46; A61K39/07; A61K39/112; A61K39/12; A61K39/145; A61K39/155; A61K39/165; A61K39/205; A61K39/21; A61K48/00; A61P19/02; A61P29/00; A61P31/12; A61P35/02; A61P37/06; A61P37/08; C12N7/00; C12N15/85; C12N15/09; (IPC1-7): C12N15/09; A61K31/711; A61K38/00; A61K38/21; A61K38/22; A61K38/46; A61K39/07; A61K39/112; A61K39/12; A61K39/145; A61K39/155; A61K39/165; A61K39/205; A61K39/21; A61K48/00; A61P19/02; A61P29/00; A61P31/12; A61P35/02; A61P37/06; A61P37/08
Attorney, Agent or Firm:
Kazuo Sato (2 outside)