Title:
【発明の名称】脂質及び脂質含有粒子のグリコシル化、及びそれから誘導される診断及び治療方法及び物質
Document Type and Number:
Japanese Patent JPH08507516
Kind Code:
A
Abstract:
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced glycosylation endproducts such as AGE-peptides, or a compound which forms advanced glycosylation endproducts, to form materials or particles known as AGE-lipids. AGE-lipids have been implicated in the aging process, the abnormal formation of lipofuscin and in various disease states such as diabetes and atherosclerosis. Diagnostic methods are contemplated, extending in utility from the detection of the onset and course of conditions in which variations in lipid oxidation, AGE-lipid levels, LDL levels, apolipoprotein levels, apolipoprotein receptor binding the like, may be measured, to drug discovery assays. Corresponding methods of treatment and pharmaceutical compositions are disclosed that are based on an active ingredient or ingredients that demonstrates the ability to modulate the levels of all of the foregoing markers of lipid oxidation.
Inventors:
Bucara Richard Jay
Vlassarah Helen
Ceramy Antony
Vlassarah Helen
Ceramy Antony
Application Number:
JP51994894A
Publication Date:
August 13, 1996
Filing Date:
November 12, 1993
Export Citation:
Assignee:
The Picower Institute For Medical Research
International Classes:
G01N33/53; A61K9/127; A61K31/00; A61K31/155; A61K31/195; A61K31/415; A61K31/70; A61K35/16; A61K38/00; A61K38/17; A61K39/395; A61K45/00; A61P9/10; A61P13/02; A61P15/00; A61P17/00; A61P43/00; G01N21/31; G01N33/533; G01N33/68; G01N33/92; (IPC1-7): A61K45/00; A61K9/127; A61K31/155; A61K31/195; A61K31/70; A61K35/16; A61K38/00; G01N33/53
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)