【発明の名称】グリコシルホスファチジルイノシトール特異的ホスホリパーゼDタンパク質及びその使用

Japanese Patent JP2002533119

A

Glycosyl phosphatidy linositol specific phospholipase D (GPI-PLD) proteins and their medical uses are disclosed, in particular in the treatment and diagnosis of diabetes and complications of diabetes such as insulin resistance, liver dysfunction, disorders involving pancreatectomies and conditions mediated by a product of an infectious organism which is capable of inhibiting GPI-PLD, such as septic shock. The present invention further relates to variant GPI-PLD polypeptides modified at the phosphorylation site at amino acids 689-692 of the mature human wild-type protein.

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Julian Shofield
Thomas William Raidmater

JP2000591177A

October 08, 2002

December 23, 1999

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University College London

C12N15/09; A61K38/46; A61K47/48; A61K48/00; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P31/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/16; C12N9/20; C12Q1/02; A61K38/00; (IPC1-7): C12N15/09; A61K38/46; A61K47/48; A61K48/00; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P31/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/16; C12Q1/02

Masatake Shiga (7 outside)

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