Title:
【発明の名称】アデノ随伴ウイルス2による感染のためのコレセプターとしてのヒト線維芽細胞増殖因子レセプター1
Document Type and Number:
Japanese Patent JP2002533128
Kind Code:
A
Abstract:
The present invention relates generally to the fields of gene therapy. More particularly, it concerns gene transfer using adeno-associated virus and methods of increasing transcription and promoting replication of transgenes. The present invention shows that AAV requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for successful viral entry into the host cell. Methods and compositions for exploiting this finding in AAV vector-mediated gene therapy are disclosed.
Inventors:
Sri Bastava, Arun
Chin, Kayun
Marr, Kathryn
Hansen, Jonathan
Butterfly, schanzen
Dawaki, Balabani
Chin, Kayun
Marr, Kathryn
Hansen, Jonathan
Butterfly, schanzen
Dawaki, Balabani
Application Number:
JP2000591202A
Publication Date:
October 08, 2002
Filing Date:
December 29, 1999
Export Citation:
Assignee:
Advanced Research and Technology Institute
International Classes:
C12N15/09; A61K31/7084; A61K31/7088; A61K35/76; A61K48/00; A61P1/00; A61P1/16; A61P1/18; A61P7/00; A61P11/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P35/00; C07K14/71; C12N15/12; C12N15/864; (IPC1-7): C12N15/09; A61K31/7084; A61K31/7088; A61K48/00; A61P1/00; A61P1/16; A61P1/18; A61P7/00; A61P11/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P35/00
Attorney, Agent or Firm:
Shusaku Yamamoto