Title:
【発明の名称】細胞活性調整のためのヒアルロン酸およびその誘導体
Document Type and Number:
Japanese Patent JPH10504828
Kind Code:
A
Abstract:
A method for the modulation of cellular activity of tissue and cells expressing a high affinity cell-surface receptor for hyaluronic acid, for example an adhesion molecule (for example, ICAM-1, HARLEC and CD44) and a Regulatory molecule (for example, RHAMM) of a human is provided the method comprising the administration of a non-toxic effective amount of a form of hyaluronic acid) (for example, hyaluronic acid, a salt thereof, (for example, sodium hyaluronate having a molecular weight less than 750,000 daltons, (for example, 225,000 daltons), for example from Hyal Pharmaceutical Corporation within the range of 150,000-225,000 daltons and those disclosed in U.S. Patent Application 08/143,983, molecular weight fractions of a form of sodium hyaluronate (for example, fractions disclosed in Canadian Letters Patent 1205031 (to Fidia) such as those from 50,000-100,000 daltons, 250,000-350,000 daltons and 500,000-730,000 daltons, or other fractions, homologues, analogues, derivatives, complexes, esters, fragments and/or sub units of hyaluronic acid and/or combinations thereof) and/or hyaluronic acid mimicking molecules to a human to modulate cellular activity of tissues and/or cells expressing a high affinity cell-surface receptor for hyaluronic acid, for example, an adhesion molecule and a Regulatory molecule in the human body, in a pharmaceutical excipient tolerable by the human (for example, sterile water).
Inventors:
Ascuray, Samuel Simon
Application Number:
JP50837196A
Publication Date:
May 12, 1998
Filing Date:
August 11, 1995
Export Citation:
Assignee:
Hyal Pharma Corporation
International Classes:
A61K9/00; A61K31/135; A61K31/14; A61K31/19; A61K31/192; A61K31/196; A61K31/375; A61K31/405; A61K38/00; A61K31/407; A61K31/44; A61K31/5415; A61K31/715; A61K31/728; A61K38/21; A61K45/00; A61K45/06; A61K47/00; A61K47/36; A61P9/00; A61P29/00; A61P31/12; A61P35/00; A61P43/00; (IPC1-7): A61K31/725; A61K45/00; A61K38/21; A61K38/00; A61K31/375; A61K31/19; A61K31/14; A61K31/135
Attorney, Agent or Firm:
Nobuyuki Iida