Title:
【発明の名称】ロイコトリエン生合成の阻害剤としてのイミノキシカルボキシレート類及び誘導体
Document Type and Number:
Japanese Patent JP2001518050
Kind Code:
A
Abstract:
The present invention relates to a compound of formula W-X-Q-Y-CH(R1)-O-N=C(R2)-A-COM or a pharmaceutically acceptable salt thereof wherein W is optionally substituted aryl or heteroaryl; X is a valence bond, or methylene, divalent alkylene, alkenylene, alkynylene or alkyloxy; Q is a valence bond, or -O-, -S-, >NR4 or >NCOR5; Y is optionally substituted phenyl, biphenyl, naphthyl, tetrahydronaphthyl, indolyl, pyridyl, or benzo[b]thienyl, thienyl, thiazolyl, or thiazolylphenyl; R1 is alkyl, cycloalkyl, alkoxyalkyl, aryl or arylalkyl, heteroaryl or heteroarylalkyl; R2 is hydrogen, alkyl or hydroxyalkyl; A is a valence bond or is selected from alkylene, alkenylene, alkynylene, cycloalkylene, phenylene, pyridylene, thienylene and furylene; and M is a pharmaceutically acceptable, metabolically cleavable group, -OR6, -NR6R7, -NH-tetrazoyl, -NH-2-, 3-, or 4-pyridyl, and -NH-2-, 4-, or 5-thiazolyl which inhibit leukotriene biosynthesis and are useful in the treatment of inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting lipoxygenase activity and leukotriene biosynthesis.
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Inventors:
Burutxu, de doubling
Vertia, Pramilla
Collasa, Theodozy
Stewart, Andrew O
Vertia, Pramilla
Collasa, Theodozy
Stewart, Andrew O
Application Number:
JP50505896A
Publication Date:
October 09, 2001
Filing Date:
June 28, 1995
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
A61K31/426; A61K31/428; A61K31/437; A61K31/4406; A61K31/4409; A61K31/4433; A61K31/4439; A61K31/444; A61K31/47; A61K31/4709; A61K31/498; A61K31/505; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/06; A61P27/14; A61P43/00; C07D213/30; C07D215/14; C07D215/22; C07D215/227; C07D215/36; C07D235/12; C07D239/26; C07D241/42; C07D263/56; C07D277/24; C07D277/64; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/04; C07D417/12; C07D513/04; (IPC1-7): C07D213/30; A61K31/426; A61K31/428; A61K31/437; A61K31/4406; A61K31/4409; A61K31/4433; A61K31/4439; A61K31/444; A61K31/47; A61K31/4709; A61K31/498; A61K31/505; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/06; A61P27/14; A61P43/00; C07D215/14; C07D215/22; C07D215/36; C07D235/12; C07D239/26; C07D241/42; C07D263/56; C07D277/24; C07D277/64; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/04; C07D417/12; C07D513/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)