Title:
【発明の名称】イミダゾリジルマクロライド類
Document Type and Number:
Japanese Patent JP3098032
Kind Code:
B2
Abstract:
Imidazolidyl macrolides of the general structural Formula I: have been prepared from suitable precursors by alkylation and/or arylation at C-3= and/or C-4= of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
Inventors:
Greet, mark
Sinclair, Peter Theei
Wang, Frederik
Wybrato, Machine Jay
Sinclair, Peter Theei
Wang, Frederik
Wybrato, Machine Jay
Application Number:
JP50544493A
Publication Date:
October 10, 2000
Filing Date:
September 02, 1992
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/395; A61K31/4178; A61K31/4184; A61K31/422; A61K31/423; A61K31/427; A61K31/428; A61K31/435; A61K31/436; C07H19/01; A61K31/70; A61K31/7056; A61P37/06; C07D498/12; C07D498/18; C07H7/06; C07H15/04; C07H19/02; A61K; C07D; (IPC1-7): C07D498/18; A61K31/4178; A61K31/4184; A61K31/422; A61K31/423; A61K31/427; A61K31/428; A61K31/436; A61P37/06
Domestic Patent References:
| JP61148181A |
Other References:
【文献】国際公開91/2736(WO,A1)
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)