Title:
【発明の名称】脊椎動物における体脂肪蓄積、インシュリン抵抗、高インシュリン、及び高血糖の長期削減のための改良された方法
Document Type and Number:
Japanese Patent JPH06511480
Kind Code:
A
Abstract:
A process for the long term modification and regulation of lipid and glucose metabolism-generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these being the hallmarks of noninsulin dependent, or Type II diabetes)-by administration to a vertebrate, animal or human, of a dopamine agonist and a prolactin stimulator. The dopamine agonist and prolactin stimulator are administered in daily dosages, respectively, at a time of day dependent on the normal circadian rhythm of fat and lean members of a similar species. Decreases in body fat deposits result by treatment of an obese species on a daily timed sequence based on circadian rhythms of the peak prolactin, or peak prolactin and peak glucocorticosteroid, blood level established for lean insulin sensitive members of a similar species. The dopamine agonist is administered at the time of, or just after the time of peak plasma prolactin concentration found in lean animals of the same species and the prolactin stimulator is administered at a time just before the plasma prolactin rhythm reaches its peak in lean animals. Insulin resistance, and hyperinsulinemia or hyperglycemia, or both, can also be controlled in humans on a long term basis by treatment corresponding to that of the treatment for obesity. The short term daily injections reset hormonal timing in the neural centers of the brain to produce long term effects.
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Inventors:
Shincotta, Anthony H
Myr, Albert H
Myr, Albert H
Application Number:
JP50154293A
Publication Date:
December 22, 1994
Filing Date:
June 24, 1992
Export Citation:
Assignee:
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Ergo Science, Inc.
Ergo Science, Inc.
International Classes:
A61K31/00; A61K31/13; A61K31/137; A61K31/15; A61K31/166; A61K31/195; A61K31/221; A61K31/35; A61K31/352; A61K31/40; A61K31/405; A61K31/435; A61K31/439; A61K31/445; A61K31/4515; A61K31/454; A61K31/46; A61K31/475; A61K31/48; A61K31/496; A61K31/54; A61K31/5415; A61K31/55; A61K31/551; A61K31/5513; A61K31/695; A61K38/22; A61K45/00; A61K45/06; A61P3/06; A61P3/08; A61P3/10; C07D457/00; C07D457/04; G01N33/74; (IPC1-7): A61K45/00; A61K31/48; A61K45/00
Attorney, Agent or Firm:
Makoto Kanesaka (1 person outside)