Title:
【発明の名称】改良された取り込みおよびその他の性質を持つ誘導化オリゴヌクレオチド
Document Type and Number:
Japanese Patent JP2823959
Kind Code:
B2
Abstract:
Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, a lipid soluble vitamin, an RNA cleaving complex, a metal chelator, a porphyrin, an alkylator, a pyrene, a hybrid photonuclease/intercalator, or an aryl azide photocrosslinking agent exhibit increased cellular uptake and other properties. The substituent can be attached at the 2'-position of the functionalized nucleoside via a linking group. If at least a portion of the remaining linked nucleosides are 2'-deoxy-2'-fluoro, 2'-O-methoxy, 2'-O-ethoxy, 2'-O-propoxy, 2'-O-aminoalkoxy or 2'-O-allyloxy nucleosides, the substituent can be attached via a linking group at any of the 3'- or the 5'-positions of the nucleoside or on the heterocyclic base of the nucleoside or on the inter-nucleotide linkage linking the nucleoside to an adjacent nucleoside.
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Inventors:
Manoharan, Macia
Cook, Philip Dunn
Bennett, Clarence Frank
Cook, Philip Dunn
Bennett, Clarence Frank
Application Number:
JP50796193A
Publication Date:
November 11, 1998
Filing Date:
October 23, 1992
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
C07H21/00; C07H23/00; C07J43/00; C07J51/00; C07H21/04; C12N15/09; G01N33/50; (IPC1-7): C07H21/00; C12N15/09; G01N33/50
Other References:
【文献】米国特許4958013(US,A)
【文献】J.Am.Chem.Soc.,111[18],(1989),p6966~6976
【文献】J.Am.Chem.Soc.,111[18],(1989),p6966~6976
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)