Title:
【発明の名称】P53とMDM2の間の相互作用の阻害剤
Document Type and Number:
Japanese Patent JP2001500365
Kind Code:
A
Abstract:
The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.
Inventors:
Rain, david
Bettger, Walker
Bettgar, Angelica
Pixley, Stephen
Hochkeppel, Heinz Kurt
Garcia-Echeveria, Carlos
Chene, Patrick
Fure, Pascal
Bettger, Walker
Bettgar, Angelica
Pixley, Stephen
Hochkeppel, Heinz Kurt
Garcia-Echeveria, Carlos
Chene, Patrick
Fure, Pascal
Application Number:
JP50477598A
Publication Date:
January 16, 2001
Filing Date:
July 04, 1997
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
Cancer Research Campaign Technology Limited
Cancer Research Campaign Technology Limited
International Classes:
G01N33/53; A61K38/00; A61K45/00; A61P35/00; C07K7/04; C07K7/06; C07K7/08; C07K14/82; C12N15/09; C12Q1/68; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61P35/00; C07K7/06; C07K7/08; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)