Title:
【発明の名称】MAdCAM―1媒介性相互作用の阻害剤およびその使用方法
Document Type and Number:
Japanese Patent JP2000503203
Kind Code:
A
Abstract:
The present invention provides novel compounds comprising peptide sequences which mimic the conserved amino acid motif LDTSL of MAdCAM-1 and which have groups bonded to the N- and C-termini. Also provided are methods of inhibiting the interaction of a cell bearing a ligand of MAdCAM-1, such as human alpha4beta7, with MAdCAM-1 or a portion thereof (e.g., the extracellular domain), comprising contacting the cell with a compound of the present invention.
Inventors:
Schwender, Charles F.
Shrov, Hitesh N.
Shrov, Hitesh N.
Application Number:
JP52538197A
Publication Date:
March 21, 2000
Filing Date:
January 03, 1997
Export Citation:
Assignee:
Leuco Site, Incorporated
International Classes:
C12N15/09; A61K31/00; A61K38/00; A61P1/00; A61P3/00; A61P3/10; A61P7/00; A61P29/00; A61P43/00; C07K5/02; C07K5/072; C07K5/08; C07K5/083; C07K5/113; C07K5/117; C07K9/00; C07K14/705; C07K19/00; C12N5/10; C12P21/02; C12R1/91; (IPC1-7): C12N15/09; A61P1/00; A61P3/10; A61P7/00; A61P29/00; A61P43/00; A61K38/00; C07K9/00; C07K14/705; C07K19/00
Attorney, Agent or Firm:
Yoshinori Hosoda