Title:
【発明の名称】多形相Iのフィナステライド
Document Type and Number:
Japanese Patent JP2742409
Kind Code:
B2
Abstract:
Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17β-carboalkoxy-4-aza-5α-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride.Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.
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Inventors:
Wolf H. Dolling
The Ames Macquarie
Lichyard J. Barsorona
The Ames Macquarie
Lichyard J. Barsorona
Application Number:
JP25937396A
Publication Date:
April 22, 1998
Filing Date:
September 30, 1996
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/58; C07F3/00; C07J73/00; C07J75/00; H04N5/74; C07J9/00; (IPC1-7): C07J73/00; C07J75/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)