Title:
【発明の名称】脳又は心臓の環状ヌクレオチドによってゲーティングされるイオンチャンネル化合物及びその使用
Document Type and Number:
Japanese Patent JP2002508930
Kind Code:
A
Abstract:
The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein. The present invention also provides a method for testing whether a compound affects the expression of a BCNG protein or a BCNG-related protein. In addition, the present invention further provides a method for identifying a compound capable of interacting with a BCNG protein or a BCNG-related protein. Also, the present invention provides a method for identifying a compound capable of modulating BCNG protein or BCNG-related protein activity. Further, the present invention also provides a method of treating a condition in a subject which comprises administering to the subject an amount of the provided compound, effective to treat the condition. Finally, the present invention provides a pharmaceutical composition which comprises the provided compound and a pharmaceutically acceptable carrier.
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Inventors:
Candel, Eric Earl
Santoro, Veena
Birch, dusan
Siegelbaum, Stephen
Tibs, Gareth
Grant, Seth
Santoro, Veena
Birch, dusan
Siegelbaum, Stephen
Tibs, Gareth
Grant, Seth
Application Number:
JP2000525534A
Publication Date:
March 26, 2002
Filing Date:
December 23, 1998
Export Citation:
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
International Classes:
A61K9/08; A61K9/12; A61K9/16; A61K9/20; A61K45/00; A61P9/00; A61P25/08; A61P25/16; A61P25/28; C07K14/47; C07K14/705; C07K16/18; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/02; C12N5/10; C12N15/00; C12N15/09; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/50; G01N33/15; G01N33/53; G01N33/566; A61K38/00; (IPC1-7): C12N15/09; A61K9/08; A61K9/12; A61K9/16; A61K9/20; A61K45/00; A61P9/00; A61P25/08; A61P25/16; A61P25/28; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)