Title:
【発明の名称】インテグリン受容体拮抗剤としてのイソオキサゾリンおよびイソオキサゾール誘導体
Document Type and Number:
Japanese Patent JPH11506436
Kind Code:
A
Abstract:
This invention relates to novel heterocycle compounds including but not limited to 3-[3-[3-(imidazolin-2-yl amino)propyloxy]isoxazol-5-ylcarbonylamino]-2-(benzyloxycarbonylamino)-propionic acid, which are useful as antagonists of the alpha v beta 3 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion and the treatment of angiogenic disorders, inflammation, bone degradation, tumors, metastases, thrombosis, and other cell aggregation-related conditions.
Inventors:
Boss, Machine Ernst
Jyadav, pravacal kondaji
Small Hair, The Juan Marie
Butt, Douglas Guy
Pitsutsu, William Jiyoung
Vit Yak, Jiyoung
Jyadav, pravacal kondaji
Small Hair, The Juan Marie
Butt, Douglas Guy
Pitsutsu, William Jiyoung
Vit Yak, Jiyoung
Application Number:
JP53589996A
Publication Date:
June 08, 1999
Filing Date:
May 24, 1996
Export Citation:
Assignee:
The DuPont Merck Pharmaceuticals Company
International Classes:
A61K31/42; A61K31/44; A61K31/505; A61P7/02; A61P9/14; A61P43/00; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D471/04; (IPC1-7): C07D413/12; A61K31/42; A61K31/44; A61K31/505; C07D413/06; C07D413/14; C07D417/12; C07D471/04
Attorney, Agent or Firm:
Chika Takagi (2 outside)