Title:
【発明の名称】特異的に発現するリーシュマニア遺伝子及び蛋白質
Document Type and Number:
Japanese Patent JPH09502091
Kind Code:
A
Abstract:
Differentially expressed Leishmania genes and proteins are described. One differentially expressed gene (A2) is expressed at significantly elevated levels (more than about 10 fold higher) in the amastigote stage of the life cycle when the Leishmania organism is present in macrophages than in the free promastigote stage. The A2 gene encodes a 22 kD protein (A2 protein) that is recognized by kala-azar convalescent serum and has amino acid sequence homology with an S-antigen of Plasmodium falciparum Vietnamese isolate VI. Differentially expressed Leishmania genes and proteins have utility as vaccines, diagnostic reagents, as tools for the generation of immunological reagents and the generation of attenuated variants of Leishmania.
Inventors:
Matlaszewski, Gregory
Charrest, Hugs
Charrest, Hugs
Application Number:
JP50785195A
Publication Date:
March 04, 1997
Filing Date:
September 01, 1994
Export Citation:
Assignee:
McGill University
International Classes:
C12N15/09; A61K35/68; A61K39/008; A61K39/395; A61P33/02; C07K14/44; C07K16/20; C12N1/10; C12N15/30; C12P21/02; C12P21/08; A61K39/00; C12R1/19; C12R1/90; H01S3/02; (IPC1-7): C12N15/09; A61K39/008; C07K14/44; C12N1/10; C12P21/02; C12P21/08
Attorney, Agent or Firm:
Wakabayashi Tadashi