Title:
【発明の名称】物質の制御送達用のリポスフェア
Document Type and Number:
Japanese Patent JP3233402
Kind Code:
B2
Abstract:
Solid, water-insoluble lipospheres formed of a solid hydrophobic core having a layer of a phospholipid embedded on the surface of the core, containing biologically active agent in the core, in the phospholipid, adhered to the phospholipid, or a combination thereof, are disclosed for use in providing extended release of active agent, including drugs such as vaccines and anesthetics, insect control agents such as insecticides and repellents, and agricultural compounds such as fertilizers, fungicides, pesticides, and herbicides. Lipospheres can be prepared by a melt technique or a solvent technique, summarized as: (1) forming a liquid solution or suspension of the agent by either melting the agent, or dissolving or dispersing the agent in a liquid vehicle, to form a mixture of liquid agent that solidifies at room temperature or greater; (2) adding phospholipid and an aqueous solution to the liquid agent to form a suspension; (3) mixing the suspension at a temperature above the melting temperature until a homogeneous fine dispersion is obtained; and then (4) rapidly cooling the dispersion to below the melting temperature of the liquid mixture containing the agent. Agent can also be added to the phospholipid or mixed with the resulting lipospheres. The agent containing lipospheres have several advantages over other delivery systems, including emulsions, vesicles and liposomes, including stability, low cost of reagents, ease of manufacture, high dispersibility in an aqueous medium, a release rate for the entrapped substance that is controlled by the phospholipid coating and the carrier. Examples demonstrate the effective administration of anesthetics, antigens, and insect repellent (DEET).
Inventors:
Dom, Abraham Jay.
Mania, Manoge
Mania, Manoge
Application Number:
JP50146091A
Publication Date:
November 26, 2001
Filing Date:
November 08, 1990
Export Citation:
Assignee:
SIOS Nova Incorporated
International Classes:
A01N25/26; A61K9/127; A61K9/14; A61K9/16; A61K9/50; A61K47/24; B01J13/02; (IPC1-7): A61K9/16; A01N25/26; A61K9/50; A61K47/24; B01J13/02
Domestic Patent References:
| JP6156122A | ||||
| JP63253031A | ||||
| JP6229511A | ||||
| JP5922651A |
Other References:
【文献】米国特許4610868(US,A)
Attorney, Agent or Firm:
Shusaku Yamamoto