Title:
【発明の名称】マトリックス金属プロテイナーゼおよびTNFα分泌の大環状阻害剤
Document Type and Number:
Japanese Patent JP2001509151
Kind Code:
A
Abstract:
Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
Inventors:
David Wittsen, Stephen Kay
Steinman, Douglas H
Siepard, the Gios
Sue Lien Hong
Holmes, The Ames H
Kuu, Yang
Froyansk, Alan Scott
Seamers, The Ames Bee
Micheledes, Michael Earl
Steinman, Douglas H
Siepard, the Gios
Sue Lien Hong
Holmes, The Ames H
Kuu, Yang
Froyansk, Alan Scott
Seamers, The Ames Bee
Micheledes, Michael Earl
Application Number:
JP53103198A
Publication Date:
July 10, 2001
Filing Date:
January 07, 1998
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
A61K31/395; A61K31/40; A61K31/404; A61K31/4188; A61K31/427; A61K31/4427; A61K31/4523; A61K31/553; A61K38/00; A61K38/55; A61P1/02; A61P7/00; A61P11/06; A61P19/02; A61P19/10; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D225/06; C07D245/02; C07D245/06; C07D267/00; C07D273/01; C07D413/04; C07D413/06; C07D413/12; C07D417/06; C07D417/12; C07D487/08; C07K5/078; (IPC1-7): C07D225/06; A61K31/395; A61K38/00; A61P1/02; A61P7/00; A61P11/06; A61P19/02; A61P27/02; A61P29/00; C07D245/02; C07D267/00; C07D413/04; C07D487/08; C07K5/078
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)
Previous Patent: 癌化学療法における薬剤耐性に対するタキソイド復帰作用剤およびそれら...
Next Patent: ＣＣＲ５受容体リガンド、抗炎症薬および抗−ウイルス薬としての置換ビ...
Next Patent: ＣＣＲ５受容体リガンド、抗炎症薬および抗−ウイルス薬としての置換ビ...