Title:
【発明の名称】プロカインアミドおよびNAPAのマレイミド付加物結合体
Document Type and Number:
Japanese Patent JPH09507841
Kind Code:
A
Abstract:
Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: +TR wherein: X=hydrogen or acetyl; R1=an alkyl group having 1 to 3 carbon atoms; m=an integer from 2 to 10; R2=an alkyl, cycloalkyl or aryl group having 2 to 10 carbon atoms; Z=a poly(amino acid); and n=1 to p where p=MW of Z/1000. The derivatives include maleimide conjugates of proteins or poly(amino acids), enzymes, enzyme donor polypeptides and labeling substances. Novel activated hapten intermediates useful in the preparation of the conjugates and methods for synthesis of the hapten intermediates and derivatives are also disclosed.
Inventors:
Sigler, Gerald F.
Walter, Charles F.
Durant, Charles E.
Tony, Gracy
Klein, Frank E.
Dawn, Alan Earl.
Walter, Charles F.
Durant, Charles E.
Tony, Gracy
Klein, Frank E.
Dawn, Alan Earl.
Application Number:
JP51695595A
Publication Date:
August 12, 1997
Filing Date:
December 16, 1994
Export Citation:
Assignee:
Boehringer Mannheim Corporation
International Classes:
A61K39/385; A61K39/395; C07D207/416; C07D207/452; C07K16/44; C08B37/00; C12N9/38; C12N9/96; C07D207/40; C07D207/44; (IPC1-7): C07D207/452; C07K16/44; C08B37/00; C12N9/38
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)