PURPOSE: To obtain a new compound useful as a preventing and treating throm bosis, arteriosclerosis, ischemic heart disease, gastric ulcer, hypertension, etc., having PGI2 receptor agonist action.
CONSTITUTION: A compound of formula I [group of formula II is group of formula III to formula VI (e is 3-5; f is 1-3; p and r are 1-4; q is 0-2; s is 0-3); A is group of formula VII to formula X (l) is 1-3; m is 1 or 2; R4 is H, 1-4C alkyl, phenyl or 1-4C alkyl substituted with one or two hetero rings groups of 4- to 7-membered mono ring containing 1 or 2 phenyls or Ns; Y is O or S), etc.; R1 is OH, 1-12C alkoxy, NR2R3 (R2 and R3 are H, 1-4C alkyl or R2, R3 and adjacent N form amino acid residue)], its nontoxic salt or its acid addition salt such as [2-(4-diphenylmethylpyrazol-2-yl)methyl-1,2,3,4,-tetrahydronaphthalen-5-yloxy]acetic acid of formula XI.
TAKAHASHI KANJI
TOKUMOTO HIDEKADO
