Title:
【発明の名称】血漿コレステロールレベルを低下させるための方法及び組成物
Document Type and Number:
Japanese Patent JP2002529740
Kind Code:
A
Abstract:
A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol is provided that includes assessing the ability of the compound to form a complex with the lipoprotein, e.g., LDL or VLDL, and then determining whether the newly formed complex causes a change in the structure of apoB-100 that results in increased binding affinity to the LDL receptor. Also disclosed is a method for lowering cholesterol in a host in need thereof, including a human, is provided that includes the administration fo an effective amount of a compound which binds to cholesterol-carrying lipoprotein (e.g. LDL or VLDL) in a manner that alters the three dimensional configuration of the lipoprotein and increases the binding affinity of the apoB-100 protein to the LDL receptor, including those on the surface of a hepatic cell.
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Inventors:
Medfaud, Russell M
Saxuna, woodai
Saxuna, woodai
Application Number:
JP2000581459A
Publication Date:
September 10, 2002
Filing Date:
November 09, 1999
Export Citation:
Assignee:
Aserodynics Incorporated
International Classes:
A61K31/00; A61K31/10; A61K31/12; A61K31/165; A61K31/166; A61K31/18; A61K31/192; A61K31/20; A61K31/222; A61K31/225; A61K31/455; A61K31/7028; A61K31/785; A61K45/06; A61P3/06; A61P9/10; G01N27/447; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/92; (IPC1-7): G01N33/92; A61K31/10; A61K31/12; A61K31/165; A61K31/166; A61K31/18; A61K31/192; A61K31/20; A61K31/222; A61K31/225; A61K31/455; A61K31/7028; A61K31/785; A61K45/06; A61P3/06; A61P9/10; G01N27/447; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)