Title:
【発明の名称】カンプトテシンおよびカンプトテシン類似体の不斉合成の方法および中間体
Document Type and Number:
Japanese Patent JP3499554
Kind Code:
B2
Abstract:
Processes for making compounds of Formulae XIV, XV, and XVII wherein R6 is lower alkyl, R7 is lower alkyl, R is lower alkyl, Y is H, F or Cl, R8 is a moiety of Formula XVIII wherein n is 1, 2, or 3, R11 is C1-C4 alkyl and R12 is the same as R11, or R11 and R12 together form cyclopentane or cyclohexane, and R13 is: (a) phenyl substituted 1 to 5 times with C3-C7 secondary alkyl or C4-C7 tertiary alkyl, or (b) selected from the group consisting of naphthyl, anthryl, and phenanthryl optionally substituted 1 to 5 times with C3-C7 secondary alkyl or C4-C7 tertiary alkyl groups, R10 is C6-C10 alkyl, aryl or alkyl aryl, and Y is H, F or Cl, are disclosed. These processes can be used to make optically enhanced and optically pure forms of the compounds, which are useful in the making of a camptothecin and analogs thereof.
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Inventors:
Commins, Daniel El
Baev Sky, Matthew F
Baev Sky, Matthew F
Application Number:
JP50145294A
Publication Date:
February 23, 2004
Filing Date:
April 23, 1993
Export Citation:
Assignee:
North Carolina State University
International Classes:
C07D213/64; C07D215/18; C07D215/20; C07D215/233; C07D215/26; C07D215/36; C07D215/38; C07D215/40; C07D215/48; C07D491/04; C07D491/052; C07D491/22; C07D215/22; (IPC1-7): C07D491/052; C07D213/64
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)