Title:
【発明の名称】ヒストリチクス菌からのコラゲナーゼ産生に応答性の遺伝子の分子クローニング
Document Type and Number:
Japanese Patent JPH08500970
Kind Code:
A
Abstract:
Genetically-engineered (E. coli) carrying vectors containing an insert that codes for non-native and native forms of (Clostridium histolyticum) collagenase. The recombinant DNA segments coding for collagenase are expressed efficiently in the transformed cells to yield enzymatically active and immunologically cross-reactive collagenase. Genetically-engineered collagenase is used for isolation of pancreatic islets, for isolation of endothelial cells, for the isolation of dispersed tumor cells, or for the treatment of "slipped disc".
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Inventors:
Lynn, Hyun-chi
Ray, Xiao-Ping
Ray, Xiao-Ping
Application Number:
JP50252194A
Publication Date:
February 06, 1996
Filing Date:
June 22, 1993
Export Citation:
Assignee:
Trigen, Inc.
International Classes:
C12N15/09; A61K38/46; A61P35/00; C07H21/04; C12N1/21; C12N9/52; C12N15/57; A61K38/00; C12R1/19; (IPC1-7): C12N15/09; A61K38/46; C07H21/04; C12N1/21; C12N9/52
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)