Title:
【発明の名称】IMPDH様結合ポケットを含む分子およびそれらをグラフィック表示することが可能なコード化データ記憶媒体
Document Type and Number:
Japanese Patent JP2000511884
Kind Code:
A
Abstract:
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
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Inventors:
Wilson, Keith Pee.
Shinchuck, Michael Dee.
Villion Systems, Inc.
Armystead, David M.
Shinchuck, Michael Dee.
Villion Systems, Inc.
Armystead, David M.
Application Number:
JP53916697A
Publication Date:
September 12, 2000
Filing Date:
April 28, 1997
Export Citation:
Assignee:
Vertex Pharmaceuticals Incorporated
International Classes:
A61K31/00; A61K31/365; A61K45/00; A61P43/00; C07K1/00; C07K1/14; C12N9/04; C12Q1/32; G06F17/30; G06F17/50; G06F19/00; (IPC1-7): C07K1/14; C12N9/04; C12Q1/32; G06F17/50
Attorney, Agent or Firm:
Shusaku Yamamoto