Title:
【発明の名称】非ペプチド性エンドセリンアンタゴニスト
Document Type and Number:
Japanese Patent JPH10508843
Kind Code:
A
Abstract:
Novel indole and indoline nonpeptide antagonists of endothelin I are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure and subarachnoid hemorrhage.
Inventors:
Beriman, Kent Alan
Bunker, Amy May
Doherty, Anetsu Marian
Edmans, The Elimie Jiyoung
Bunker, Amy May
Doherty, Anetsu Marian
Edmans, The Elimie Jiyoung
Application Number:
JP51603795A
Publication Date:
September 02, 1998
Filing Date:
October 02, 1995
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
C07D491/113; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61P9/00; A61P11/00; A61P43/00; C07D209/42; C07D405/04; C07D405/06; C07D405/14; C07D491/056; (IPC1-7): C07D209/42; A61K31/40; A61K31/415; C07D405/04; C07D405/06; C07D405/14; C07D491/113
Attorney, Agent or Firm:
Chika Takagi (2 outside)