Title:
【発明の名称】新規な7-置換19-ノルステロイド、それらの製造法、薬剤としての使用及びそれらを含有する製薬組成物
Document Type and Number:
Japanese Patent JP2717792
Kind Code:
B2
Abstract:
Novel 19-nor-steroids of the formula (I) wherein the A ring is either Re is selected from the group consisting of hydrogen, acyl and optionally substituted alkyl of 1 to 6 carbon atoms, R is methyl or ethyl, R1 is selected from the group consisting of hydroxyl, protected hydroxyl, acyloxy and alkoxy, R2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, acyl, aralkyl of 7 to 15 carbon atoms, the substituents other than hydrogen being optionally substituted or R1 and R2 together form a group selected from the group consisting of Ar is an optionally substituted 5- or 6-membered aryl and their salts with non-toxic, pharmaceutically acceptable bases and acids having antiproliferative, anti-estrogenic and/or estrogenic properties.
Inventors:
Francois Neek
Liyusian Nudelek
Mary Madeleine Bouton
Daniel Huilibert
Liyusian Nudelek
Mary Madeleine Bouton
Daniel Huilibert
Application Number:
JP3413688A
Publication Date:
February 25, 1998
Filing Date:
February 18, 1988
Export Citation:
Assignee:
Roussel-Yukraf
International Classes:
A61K31/56; A61K31/58; C07J1/00; C07J21/00; C07J31/00; C07J41/00; C07J43/00; C07J51/00; (IPC1-7): C07J21/00; A61K31/58
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)