Title:
【発明の名称】高いキラル純度のホスホロチオエート結合を有するオリゴヌクレオチド
Document Type and Number:
Japanese Patent JPH10510433
Kind Code:
A
Abstract:
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis.
Inventors:
Cook, Philip Dunn
Hawk, Glen
Hawk, Glen
Application Number:
JP50125497A
Publication Date:
October 13, 1998
Filing Date:
June 05, 1996
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
A61K31/70; A61K31/7088; A61K31/7125; A61K48/00; C12N15/09; A61P1/16; A61P25/00; A61P27/02; A61P29/00; A61P31/12; A61P31/14; A61P31/18; A61P35/00; A61P43/00; C07H21/00; C07H21/04; C12N15/113; (IPC1-7): C12N15/09; A61K31/70; A61K48/00; C07H21/04
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)
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