Title:
【発明の名称】CCKアンタゴニストに対するプロ―ドラッグ
Document Type and Number:
Japanese Patent JP3356431
Kind Code:
B2
Abstract:
Novel pro-drugs to new and unnatural depeptoids of alpha -substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the dipeptoids are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment or with use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The pro-drugs are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the pro-drugs as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject pro-drug compounds in diagnostic compositions.
Inventors:
Howell, David Christopher
Pritzard Yard, Martin Clive
Richardson, Reginald Stewart
Pritzard Yard, Martin Clive
Richardson, Reginald Stewart
Application Number:
JP51666591A
Publication Date:
December 16, 2002
Filing Date:
August 29, 1991
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/47; A61K38/00; A61P1/00; A61P1/04; A61P3/04; A61P25/00; A61P43/00; C07D209/14; C07D209/20; C07D401/12; C07D401/14; C07D403/06; C07D403/14; C07D405/06; C07D405/14; C07D409/12; C07D409/14; C07D413/06; C07D413/14; C07K5/02; C07K5/023; C07K5/06; C07K5/08; C07K5/097; C07K14/575; C07K14/655; (IPC1-7): C07D209/20; C07D401/12; C07K5/023
Domestic Patent References:
| JP549161B1 |
Other References:
Ｅｕｒ．Ｊ．Ｍｅｄ．Ｃｈｅｍ．，（１９９０），２５（１），ｐ．５３−６０
Attorney, Agent or Firm:
Chika Takagi (2 outside)