Title:
【発明の名称】アスパルチルプロテアーゼインヒビターのプロドラッグ
Document Type and Number:
Japanese Patent JP2001527062
Kind Code:
A
Abstract:
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.
Inventors:
Hale, Michael Earl.
Tongue, Roger Dee.
Baker, Christopher Tee.
Spartenstein, Andrew
Far Fine, Eric Stephen
Kardot, Istaban
Kazumielski, Weeslaw
Tongue, Roger Dee.
Baker, Christopher Tee.
Spartenstein, Andrew
Far Fine, Eric Stephen
Kardot, Istaban
Kazumielski, Weeslaw
Application Number:
JP2000526477A
Publication Date:
December 25, 2001
Filing Date:
December 23, 1998
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/34; A61K31/341; A61K31/4172; A61K31/44; A61K31/496; A61K31/66; A61K31/665; A61K31/7024; A61P31/18; A61P37/04; A61P43/00; C07C311/18; C07D307/20; C07D317/34; C07D405/12; C07F9/655; C07F9/6584; (IPC1-7): C07C311/18; A61K31/341; A61K31/665; A61P31/18; A61P37/04; A61P43/00; C07D307/20; C07F9/655; C07F9/6584
Attorney, Agent or Firm:
Shusaku Yamamoto