Title:
【発明の名称】サブスタンスPのアンタゴニストとしてのペルヒドロイソインドール誘導体
Document Type and Number:
Japanese Patent JPH10509970
Kind Code:
A
Abstract:
PCT No. PCT/FR95/01577 Sec. 371 Date May 30, 1997 Sec. 102(e) Date May 30, 1997 PCT Filed Nov. 29, 1995 PCT Pub. No. WO96/16939 PCT Pub. Date Jun. 6, 1996 (I) (Ia) New perhydroinsoindole having the general formula (I) wherein R1 is optionally substituted phenyl or is cyclohexadienyl, naphtyl, indenyl or mono or polycyclic heterocyclyl, saturated or unsaturated 5 to 9C and optionally substituted, R2 is H or halogen, OH, alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, dialkylaminoalcyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R3 is phenyl optionally substituted in position -2 by a radical alkyl or alkyloxy 1 or 2C or by OH or F, or disubstituted by CF3, and R4 is an alkyl radical containing 1 or 2C substituted by halogen or CN, N3 or -NHCN, and the radicals R which are similar or different represent H, alkyl or phenyl, in their isomer forms having the structure (Ia) or mixtures thereof, optionally their salts when they exist and preparation thereof. The new derivatives of the invention are particularly useful as antagonists of substance P.
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Inventors:
Asiyar, daniel
Payronel, Jean-Francois
Tabard, Michel
Payronel, Jean-Francois
Tabard, Michel
Application Number:
JP51834096A
Publication Date:
September 29, 1998
Filing Date:
November 29, 1995
Export Citation:
Assignee:
Loan-Poulin L'Oré Societe Anonym
International Classes:
A61K31/40; A61K31/403; A61K31/4035; A61K31/44; A61K31/4427; A61K31/4433; A61P1/00; A61P9/00; A61P11/00; A61P25/00; A61P27/02; A61P29/00; A61P43/00; C07D209/44; C07D401/06; C07D409/06; (IPC1-7): C07D209/44; A61K31/40; A61K31/44; C07D401/06; C07D409/06
Attorney, Agent or Firm:
Heiyoshi Odashima