Title:
【発明の名称】α1A-アドレナリン受容体アンタゴニストとしてのピペラジン誘導体
Document Type and Number:
Japanese Patent JPH09500883
Kind Code:
A
Abstract:
There are disclosed compounds of general formula (I). Y is a linking group, chosen from a wide range, but including -COO-, -CH2COO-, -CONH-, -CON(CH3)-, -CH2CONH-, -SO2NH-, -SO2N(CH3)- and -PO(OC2H5)NH-. W is an alkylene chain. A is a substituted phenyl group or a benzofuran or benzodioxan group. R and R1 may have many values, but R is preferably a bulky group. These compounds and their prodrugs, enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts block alpha 1A-adrenergic receptors and are thus useful for the prevention of contractions of the prostate, urethra and lower urinary tract, without affecting blood pressure.
Inventors:
Leonardi, Amedeo
Motta, Gianni
Riva, Carlo
Tester, Rodolfo
Motta, Gianni
Riva, Carlo
Tester, Rodolfo
Application Number:
JP50554695A
Publication Date:
January 28, 1997
Filing Date:
July 22, 1994
Export Citation:
Assignee:
Recordachi S.A., Chemical and Pharmaceutical Company
International Classes:
A61K31/38; A61K31/381; A61K31/495; A61K31/496; A61P25/02; A61P43/00; C07D261/08; C07D261/10; C07D263/32; C07D263/34; C07D277/20; C07D277/22; C07D277/32; C07D295/088; C07D295/12; C07D295/13; C07D295/20; C07D307/82; C07D319/18; C07D333/08; C07F9/6509; (IPC1-7): C07D295/20; A61K31/38; A61K31/495; C07D261/08; C07D261/10; C07D263/32; C07D263/34; C07D277/22; C07D277/32; C07D295/12; C07D307/82; C07D319/18; C07D333/08
Attorney, Agent or Firm:
Eiji Saegusa (2 others)