Title:
【発明の名称】ヒトHMG-COAレダクターゼ遺伝子における多型
Document Type and Number:
Japanese Patent JP2003502077
Kind Code:
A
Abstract:
This invention relates to polymorphisms in the human HMG-CoA reductase gene and corresponding novel allelic polypeptides encoded thereby. Particular polymorphisms are described in the promoter, exon 15 and introns 2, 5, 15 and 18. The invention also relates to methods and materials for analysing allelic variation in the HMG CoA reductase gene, and to the use of HMG-CoA reductase polymorphism in the diagnosis and treatment of HMG-CoA reductase mediated diseases such as dyslipidemia and other cardiovascular diseases such as myocardial infarction and stroke.
Inventors:
Ruth Eleanor March
Sara Melissa Thornton
Sara Melissa Thornton
Application Number:
JP2001505346A
Publication Date:
January 21, 2003
Filing Date:
June 19, 2000
Export Citation:
Assignee:
AstraZeneca UK Limited
International Classes:
A61K45/00; A61P3/06; A61P9/00; A61P9/10; A61P43/00; C12M1/00; C12N9/02; C12N9/04; C12Q1/68; C12Q1/6883; C12N15/09; (IPC1-7): C12N15/09; A61K45/00; A61P3/06; A61P9/00; A61P9/10; A61P43/00; C12M1/00; C12N9/02; C12Q1/68
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)