Title:
【発明の名称】ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤
Document Type and Number:
Japanese Patent JP2001526178
Kind Code:
A
Abstract:
The present invention is directed to pyrrolidine and piperidine compounds of formula (I), (wherein R<1>, R<2>, R<3>, R<4a>, R<4b>, R<4c>, R<4d>, R<4e>, R<4f>, R<4g>, R<4h>, m, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
Inventors:
Badeu, the yard
Hale, Jefrey Jay
Holson, edward
Lynch, Christopher
Matsukos, Malcom
Mills, Thunder Gee
Bourke, Scott Sea
Christopher A.
Hale, Jefrey Jay
Holson, edward
Lynch, Christopher
Matsukos, Malcom
Mills, Thunder Gee
Bourke, Scott Sea
Christopher A.
Application Number:
JP2000507374A
Publication Date:
December 18, 2001
Filing Date:
August 27, 1998
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
C07D217/02; A61K31/40; A61K31/435; A61K31/438; A61K31/4427; A61K31/443; A61K31/4433; A61K31/451; A61K31/454; A61K31/4545; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/496; A61K31/55; A61P29/00; A61P31/18; A61P37/00; C07D207/09; C07D211/14; C07D211/70; C07D211/96; C07D223/02; C07D223/16; C07D401/06; C07D401/14; C07D403/06; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D495/10; (IPC1-7): A61K31/47; A61K31/40; A61K31/435; A61K31/438; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/55; A61P29/00; A61P31/18; A61P37/00; C07D207/09; C07D211/14; C07D211/70; C07D211/96; C07D217/02; C07D223/02; C07D223/16; C07D401/06; C07D401/14; C07D403/06; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D495/10
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)