Title:
【発明の名称】組換えシュードモナスエクソトキシン:低副作用の活性イムノトキシンの構造
Document Type and Number:
Japanese Patent JP2960697
Kind Code:
B2
Abstract:
The present invention relates to various modified forms of Pseudomonas exotoxin exhibiting low toxicity to human or animal cells by itself but retaining its enzymatic activity. The modified Pseudomonas exotoxin of the present invention has ADP ribosylating activity but lacks all or part of domain II (responsible for translocation across cell membrane) of the native toxin. A preferred modified Pseudomonas exotoxin of the present invention further comprises a modification in the receptor binding domain IA of the native Toxin. Conjugates (immunotoxins) comprising a modified Pseudomonas exotoxin and a targeting carrier, such as an antibody or a growth factor, methods for producing a modified Pseudomonas exotoxin or conjugates thereof and compositions suitable for administration to a mammal for achieving targeted cytotoxin activity are also disclosed.
Inventors:
IRA ETSUCHI PASUTAN
DABITSUDO JEI FUITSUTSUGERARUDO
SANKAA ADOHYA
DABITSUDO JEI FUITSUTSUGERARUDO
SANKAA ADOHYA
Application Number:
JP13562697A
Publication Date:
October 12, 1999
Filing Date:
May 26, 1997
Export Citation:
Assignee:
IRA ETSUCHI PASUTAN
DABITSUDO JEI FUITSUTSUGERARUDO
SANKAA ADOHYA
DABITSUDO JEI FUITSUTSUGERARUDO
SANKAA ADOHYA
International Classes:
C12N15/09; A61K31/00; A61K38/00; A61K38/22; A61K39/00; A61K39/02; A61K39/104; A61K39/385; A61K39/395; A61K47/48; A61P31/04; A61P35/00; C07K14/00; C07K14/005; C07K14/195; C07K14/21; C07K14/41; C07K14/42; C07K14/48; C07K14/495; C07K14/52; C07K14/54; C07K14/55; C07K14/575; C07K14/62; C07K16/00; C07K16/28; C07K19/00; C12N1/21; C12N15/00; C12N15/62; C12P21/02; C12R1/19; C12R1/385; (IPC1-7): C12N15/09; C12N1/21
Attorney, Agent or Firm:
Takehiko Suzue