Title:
【発明の名称】レトロ-アナンダミド、高親和力及び安定性のあるカンナビノイド受容体リガンド
Document Type and Number:
Japanese Patent JP2003511478
Kind Code:
A
Abstract:
Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy, as well as suppression of the immune system, enhancement of appetite and in treatment of certain mental disorders.
Inventors:
Alexandros McCrianyannis
Kian Liu
Andrea Gautpoulos
Kian Liu
Andrea Gautpoulos
Application Number:
JP2001531094A
Publication Date:
March 25, 2003
Filing Date:
October 18, 2000
Export Citation:
Assignee:
University of Connecticut
International Classes:
C07D295/20; A61K31/16; A61K31/166; A61K31/17; A61K31/27; A61K31/5375; A61P1/00; A61P9/00; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/06; A61P31/18; A61P35/00; A61P43/00; C07C233/05; C07C233/09; C07C233/65; C07C235/06; C07C271/12; C07C275/20; C07D295/215; (IPC1-7): C07C233/05; A61K31/16; A61K31/166; A61K31/17; A61K31/27; A61K31/5375; A61P1/00; A61P9/00; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/06; A61P31/18; A61P35/00; A61P43/00; C07C233/09; C07C233/65; C07C235/06; C07C271/12; C07C275/20; C07D295/20
Attorney, Agent or Firm:
Akashi Masatake