Title:
【発明の名称】二次メッセンジャー細胞信号抑制剤
Document Type and Number:
Japanese Patent JPH08508981
Kind Code:
A
Abstract:
The invention provides a group of compounds that are effective agents to inhibit specific cellular signaling events often induced by inflammatory stimuli, to act as anti-inflammatory or immunosuppressive agents, to act as cytotoxic agents for treatment of cancers, or to be directly or indirectly antimicrobial to yeast or fungal infections. More specifically, the inventive compounds have at least one amino alcohol (or derivative thereof) functional group on a side chain attached to a core moiety. The inventive compounds are useful antagonists to control intracellular levels of specific sn-2 unsaturated phosphatidic acids and corresponding phosphatidic acid-derived diacylglycerols, intracellular cell signaling messengers which occur in response to pro-inflammatory and selectively proliferative stimuli.
Inventors:
John the Michinic
Anderina, Gale E
Crane, Jay Peter
Rice glen sea
Sankara, Prasad S
Anderina, Gale E
Crane, Jay Peter
Rice glen sea
Sankara, Prasad S
Application Number:
JP52238094A
Publication Date:
September 24, 1996
Filing Date:
March 31, 1994
Export Citation:
Assignee:
Cell Therapeutics,Inc.
International Classes:
A61K31/13; A61K31/135; A61K31/165; A61K31/40; A61K31/4015; A61K31/403; A61K31/4035; A61K31/445; A61K31/45; A61K31/47; A61K31/472; A61K31/505; A61K31/513; A61K31/517; A61K31/519; A61K31/52; A61K31/522; A61P29/00; A61P31/04; A61P35/00; A61P37/06; C07C215/08; C07C215/56; C07C217/62; C07C229/22; C07C233/36; C07C233/78; C07C233/91; C07C237/06; C07D207/404; C07D207/408; C07D209/48; C07D211/40; C07D211/76; C07D211/88; C07D217/24; C07D239/54; C07D239/90; C07D239/96; C07D295/13; C07D473/10; C07D519/00; C07D207/40; (IPC1-7): C07C233/36; A61K31/13; A61K31/135; A61K31/165; A61K31/40; A61K31/445; A61K31/47; A61K31/505; A61K31/52; C07C233/78; C07C237/06; C07D207/408; C07D209/48; C07D211/40; C07D217/24; C07D239/90; C07D473/10; C07D519/00
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)