Title:
【発明の名称】充実性腫瘍治療法及び組成物
Document Type and Number:
Japanese Patent JP2889549
Kind Code:
B2
Abstract:
A liposome composition for localizing an anti-tumor compound to a solid tumor via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer, and have sizes in a selected size range between 0.07 and 0.12 microns. After intravenous administration, the liposomes are taken up by the tumor within 24-48 hours, for site-specific release of entrapped compound into the tumor. In one composition for use in treating a solid tumor, the compound is an anthracycline antibiotic drug which is entrapped in the liposomes at a concentration of greater than about 50 mu g agent/ mu mole liposome lipid. The method results in regression of solid colon and breast carcinomas which are refractory to anthracycline antibiotic drugs administered in free form or entrapped in conventional liposomes.
More Like This:
| JP2024023208 | Treatment of pneumonia |
| WO/2000/059474 | FUSOGENIC LIPIDS AND VESICLES |
| JP2006512579 | HSC70-Specific Diagnosis and Therapy for Multidrug-Resistant Neoplastic Diseases |
Inventors:
FURANSHISU JEI MAACHIN
MAACHIN SHII UTSUDORU
KAARU RIIDOMAN
YANGU ANII YAU
MAACHIN SHII UTSUDORU
KAARU RIIDOMAN
YANGU ANII YAU
Application Number:
JP6366197A
Publication Date:
May 10, 1999
Filing Date:
March 17, 1997
Export Citation:
Assignee:
SHIKYUUSU PHARM INC
International Classes:
A61K9/127; A61K31/70; A61K38/00; A61K38/095; A61K47/44; A61K38/21; A61K38/22; A61K38/27; A61K38/43; A61K38/44; A61K38/46; A61K39/00; A61K39/015; A61K39/21; A61K39/29; A61K47/24; A61K47/34; A61K47/48; A61K49/00; A61P31/04; A61P35/00; C07F9/553; A61K; (IPC1-7): A61K9/127; A61K31/70; A61K47/34; A61K49/00
Attorney, Agent or Firm:
Shusaku Yamamoto