Title:
【発明の名称】トルエン中での高分子量ポリホスホエステルの溶液重合法
Document Type and Number:
Japanese Patent JP2002508799
Kind Code:
A
Abstract:
A process for making a high molecular weight poly(phosphoester) composition comprising: (i) a biologically active substance; and (ii) a poly(phosphoester) with the recurring monomeric units: wherein X is -O- or -NR''-, where R'' is H or alkyl; L is a divalent organic moiety, with the proviso that L cannot have the formula R' is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic, or heterocycloxy; and n is from about 25 to 2000, is described. The process comprises the steps of: (a) substantially dissolving p moles of a di-XH compound in a solvent comprising more than 75% toluene at a first temperature between about -75 DEG C. and +60 DEG C. to form a reaction mixture; (b) while maintaining the reaction mixture at the first temperature, adding q moles, where p APPROX q, of a phosphorodihalo compound; (c) gradually increasing said first temperature at a rate of less than about 1.5 DEG C. per minute as necessary to achieve a second temperature between about 0 DEG C. and 150 DEG C., and mixing the reaction mixture at the second temperature to form the polymer of formula I; and (d) isolating the polymer of formula I. (e) incorporating the biologically active substance into the polymer of formula I.
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Inventors:
Tsong Tuao
Application Number:
JP50564699A
Publication Date:
March 19, 2002
Filing Date:
June 23, 1998
Export Citation:
Assignee:
Guildford Pharmaceuticals Inc.
International Classes:
C08G79/04; (IPC1-7): C08G79/04
Attorney, Agent or Firm:
Masahiro Tanaka