Title:
【発明の名称】脳への特異的薬剤供給化合物
Document Type and Number:
Japanese Patent JP2587034
Kind Code:
B2
Abstract:
Centrally acting drug species are site-specifically/sustainedly delivered to the brain by administering to a patient in need of such treatment a therapeutically effective amount of the target drug species [D] tethered to a reduced, blood-brain barrier penetrating lipoidal form [D-DHC] of a dihydropyridine-><-pyridinium salt type redox carrier. Oxidation of the dihydropyridine carrier moiety in vivo to the ionic pyridinium salt type drug/carrier entity [D-QC]+ prevents elimination thereof from the brain, while elimination from the general circulation is accelerated, and subsequent cleavage of the quaternary carrier/drug species results in sustained delivery of the drug [D] in the brain and facile elimination of the carrier moiety [QC]+.
More Like This:
| JP5913379 | How to treat and diagnose the illness |
| WO/2000/054759 | LXR MODULATORS |
| JPWO2003082808 | Benzamide derivative |
Inventors:
NIKORASU ESU BOODAA
Application Number:
JP10194082A
Publication Date:
March 05, 1997
Filing Date:
June 14, 1982
Export Citation:
Assignee:
YUNIBAASHITEI OBU FURORIDA ZA
International Classes:
A61K31/4406; A61K31/4425; A61K31/455; A61K31/565; A61P25/00; A61P25/28; A61P43/00; C07D209/32; C07D211/90; C07D213/80; C07D213/82; C07D401/12; C07J1/00; C07J43/00; C07K14/70; A61K38/00; (IPC1-7): C07D211/90; A61K31/455; A61K31/565; C07J1/00
Domestic Patent References:
| JP5639311B2 |
Other References:
Ｃｈｅｍｉｃａｌ ａｎｄ Ｅｎｇｉｎｅｅｒｉｎｇ Ｎｅｗｓ，Ｄｅｃ．２１，１９８１，Ｐ．２４−２５，Ｒ．Ｐａｗｌｓ
Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ ６７［５］（１９７８）Ｐ．６８５−６８７，Ｎ．Ｂｏｄｏｒ他
Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ ６７［５］（１９７８）Ｐ．６８５−６８７，Ｎ．Ｂｏｄｏｒ他
Attorney, Agent or Firm:
Hirose Shoichi