Title:
【発明の名称】Na+依存性グルタマートトランスポーターの新規なスプライス変異体に関する物質と方法
Document Type and Number:
Japanese Patent JP2003535579
Kind Code:
A
Abstract:
The invention relates to the Na+ dependent glutamate transporter GLAST-1 and a splice variant thereof. A novel splice variant has been bound (GLAST-1a) which lacks exon 3 resulting in a loss of about 46 amino acids. The protein is altered in such a way that indicates altered function of the transporter. Indeed, the inventors have surprisingly determined that the splice variant has a reversed transport direction as compared to GLAST-1. Thus, the invention provides materials and methods relating to the splice variant GLAST-1a including the amino acid and nucleic acid sequence; materials and methods relating to the detection in vivo or in vitro of the GLAST-1a; and materials and methods relating to the modulation of excitatory amino acids (EAAS) signalling.
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Inventors:
Deborah Mason
Jim Francis Huget
Jim Francis Huget
Application Number:
JP2001570737A
Publication Date:
December 02, 2003
Filing Date:
March 26, 2001
Export Citation:
Assignee:
UNIVERSITY COLLEGE CARDIFF CONSULTANTS LTD
International Classes:
G01N33/50; A61K38/00; A61K39/395; A61K48/00; A61P17/02; A61P19/00; A61P19/02; C07K14/47; C07K14/705; C07K16/18; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): C12N15/09; A61K38/00; A61K39/395; A61K48/00; A61P17/02; A61P19/00; A61P19/02; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Masatake Shiga (7 outside)