Title:
【発明の名称】Aβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環
Document Type and Number:
Japanese Patent JP2003523345
Kind Code:
A
Abstract:
This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Abeta-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta-amyloid production such as Alzheimer's disease and Down's Syndrome.
Inventors:
Richard E. Olson
Thomas P. Madusky
Laurin Andrew Thompson
Andrew Jay Theven
Nen Yui One
Weiden
Hong Liu
Thomas P. Madusky
Laurin Andrew Thompson
Andrew Jay Theven
Nen Yui One
Weiden
Hong Liu
Application Number:
JP2001560210A
Publication Date:
August 05, 2003
Filing Date:
February 16, 2001
Export Citation:
Assignee:
Bristol-Myers Squibb Pharma Company
International Classes:
C07D243/10; A61K31/225; A61K31/55; A61K31/551; A61K31/5517; A61P25/28; C07C233/09; C07D243/24; C07D401/06; C07D471/04; C07D471/06; C07D471/08; C07D487/04; C07D487/06; (IPC1-7): C07C233/09; A61K31/225; A61K31/55; A61K31/551; A61K31/5517; A61P25/28; C07D243/10; C07D401/06; C07D487/04; C07D487/06
Attorney, Agent or Firm:
Yoshikazu Tani (2 outside)