【発明の名称】遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド

Title:

【発明の名称】遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド

Document Type and Number:

Japanese Patent JPH0813274

Kind Code:

B2

Abstract:

Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of HIV, herpes virus, papillomavirus and other infections is provided.

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Inventors:

Cook, Philip Dunn
Kawasaki, Andrew Mamoto

Application Number:

JP51452191A

Publication Date:

February 14, 1996

Filing Date:

August 12, 1991

Export Citation:

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Assignee:

ISIS PHARMACEUTICALS INC (US)

International Classes:

A61K31/70; A61K31/7088; A61P31/12; A61P31/22; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H21/00; C07H21/04; C07H23/00; C07J43/00; C12N9/02; C12N15/09; C12N15/113; C12P21/00; C12Q1/68; A61K38/00; A61K48/00; (IPC1-7): C12N15/09; C07H21/04; C12Q1/68

Other References:

ＮｕｃｌｅｉｃＡｃｉｄｓＲｅｓ．，１７（１９８９）Ｐ．２３９−２５２

Attorney, Agent or Firm:

Kyozo Yuasa (5 people outside)

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