Title:
【発明の名称】TIE―2レセプターリガンド(TIEリガンド―3;TIEリガンド―4)およびそれらの使用
Document Type and Number:
Japanese Patent JP2000513932
Kind Code:
A
Abstract:
The present invention provides for an isolated nucleic acid molecule encoding a member of the TIE ligand family. The present invention also provides for an isolated nucleic acid molecule encoding TIE ligand-3 or TIE ligand-4. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3 or TIE ligand-4. The invention also provides an antibody which specifically binds TIE ligand-3 or TIE ligand-4. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
Inventors:
Valenzuela, David M.
Johns, Pamela F.
Jan Kopoulos, George Dee.
Johns, Pamela F.
Jan Kopoulos, George Dee.
Application Number:
JP50337698A
Publication Date:
October 24, 2000
Filing Date:
June 19, 1997
Export Citation:
Assignee:
Regeneron Pharmaceuticals, Inc.
International Classes:
A61K38/00; A61K38/18; A61K45/00; A61K51/00; A61P35/00; C07K14/17; C07K14/47; C07K14/515; C07K14/71; C07K14/745; C07K16/18; C12N1/15; C12N1/19; C12N15/09; C12N1/21; C12N5/10; C12N15/12; C12N15/85; C12P21/02; C12P21/08; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61K51/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08
Attorney, Agent or Firm:
Shusaku Yamamoto