Title:
【発明の名称】2―ピリミジンアミン誘導体およびその製造方法
Document Type and Number:
Japanese Patent JP2001503047
Kind Code:
A
Abstract:
Compounds of general formula (1)are described wherein:Ar is an optionally substituted aromatic group;R2 is a hydrogen or halogen atom or a group -X1-R2a where X1 is a direct bond or a linker atom or group, and R2a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group;R3 is an optionally substituted heterocycloalkyl group;and the salts, solvates, hydrates and N-oxides thereof.The compounds are selective protein tyrosine kinase inhibitors, particularly the kinases ZAP-70 and syk and are of use in the prophylaxis and treatment of immune or allergic diseases and diseases involving inappropriate platelet activation.
Inventors:
Davis, peter, david
Moffat, David, Festas, Charles
Batcher, mark, james
Hutchings, Martin, Clive
Parry, David, Mark
Moffat, David, Festas, Charles
Batcher, mark, james
Hutchings, Martin, Clive
Parry, David, Mark
Application Number:
JP52018498A
Publication Date:
March 06, 2001
Filing Date:
October 27, 1997
Export Citation:
Assignee:
Celtec Therapeutics Limited
International Classes:
A61K31/506; A61K31/5377; A61K31/541; A61K31/551; A61P7/00; A61P11/00; A61P19/02; A61P37/00; A61P43/00; C07D401/04; C07D401/14; (IPC1-7): C07D401/04; A61K31/506; A61K31/5377; A61K31/541; A61K31/551; A61P7/00; A61P11/00; A61P37/00; A61P43/00; C07D401/14
Attorney, Agent or Firm:
Akira Asamura (3 outside)