Title:
【発明の名称】フッ素化側鎖を有する3-カルボキシステロイド
Document Type and Number:
Japanese Patent JPH09503228
Kind Code:
A
Abstract:
The present invention provides a compound of formula (I), wherein A is a bond or a straight or branched C1-C6 alkylene chain; W is a group -R1, -OR2, -NR3R4 or (a) wherein: Y is oxygen or sulphur; R1, R2 and R4 are: a C1-C10 alkyl group, substituted by one or more fluorine atoms; or a C6-C15 cycloalkylalkyl group, substituted by one or more fluorine atoms; or an aryl group, substituted by one or more fluorine atoms; or a C7-C15 arylalkyl group, substituted by one or more fluorine atoms; R3 and each of R5, R6, and R7, independently, are hydrogen, or a C1-C10 alkyl group, unsubstituted or substituted by one or more fluorine atoms, or a C6-C15 cycloalkylalkyl group, unsubstituted or substituted by one or more fluorine atoms; or an aryl group, insubstituted or substituted by one or more fluorine atoms; or a C7-C15 arylalkyl group, unsubstituted or substituted by one or more fluorine atoms; provided that when W is a group (b) at least one of R5, R6 and R7 is different from hydrogen and contains at least one fluorine atom, and the pharmaceutically acceptable salts thereof. The compounds of formula (I) and their salts are 5 alpha -reductase inhibitors.
Inventors:
Pants collar, Achille
Neshi, Maruella
Day Sale, Enrico
Neshi, Maruella
Day Sale, Enrico
Application Number:
JP50539495A
Publication Date:
March 31, 1997
Filing Date:
July 07, 1995
Export Citation:
Assignee:
Falmatia Esset Pear
International Classes:
A61K31/56; A61P3/00; C07J3/00; C07J9/00; C07J31/00; C07J41/00; (IPC1-7): C07J41/00; A61K31/56; C07J3/00; C07J9/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)